The teams play Saturday at Gillette Stadium, and a Patriots win would wrap up an 11th consecutive AFC East title.
A Bills win would create a tie heading to Week 17, where both will host division rivals to close the season.
The Patriots would win the division if the teams finish tied based on record vs. common opponents.
Outside of the division, the Chiefs win over Denver in the snow keeps Kansas City a game back in the AFC.
Assuming the Chiefs win out, the Patriots would need two wins to capture a first-round bye as the Chiefs own the head-to-head tiebreaker.
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