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Bills vs Patriots: Patriots vs. Bills odds, line, spread: 2019 NFL picks, best Week 16 …

New England is a 6.5-point favorite in the latest Patriots vs. Bills odds, while the over-under is 37 after the total opened at 38.5.

It has nailed its recent top-rated NFL picks, entering Week 16 of the 2019 NFL schedule on a strong 33-22 run that dates back to last season.

It’s also on an incredible 95-65 roll on top-rated NFL picks that dates back to the 2017 season.

Now, it has broken down Patriots vs. Bills.

New England has the pedigree, but that doesn’t mean it will cover the Patriots vs. Bills spread on Saturday.